SynaptaGenX is an amino acid supplement carefully formulated to balance the specific combination of neurotransmitters (Serotonin, Endorphin, GABA, Dopamine) to:
- Regulate mood
- Reduce drug and alcohol cravings
- Reduce food cravings
- Enhance energy
- Reduce stress
- Increase focus and attention
- Lower the risk of addiction relapse
SynaptaGenX – Helps Support Healthy Cravings, Enhanced Energy, and Reduced Stress; Maintain Mood Health, Optimal Brain Health, and Overall Wellness*
We all want to have the ability to control factors that influence our health and happiness. There is nothing more depressing and draining on an individual than a feeling of complete and total defeat; the inability to be in control of your life and circumstances; and the sense of helplessness and hopelessness that creates, especially when it comes to your health. Feeling like you have no control over your body, your desires, or your health can be devastating.
The brain reward cascade is a sequence of neurotransmitter transactions that starts with serotonin and culminates with dopamine. In individuals with an excessive craving for food and other pleasure-satisfying substances and activities, dopamine deficiency is usually the culprit and due to an association with the dopamine D2 receptor gene (DRD2) A1 allele and other polymorphisms (gene variations) involved in the brain reward cascade. (Blum et al., 1990a; Stice et al., 2008; Volkow et al., 2009).
This reduced dopamine release and/or receptivity has been described as reward deficiency syndrome (RDS) by Kenneth Blum, Ph.D. [Blum et al, 1996]. Dr. Blum is considered the father of psychiatric genetics and nutrigenomics.
Those suffering from RDS are unable to produce an adequate feeling of well-being and consequently often self-medicate with substances that help raise the levels of “feel good” chemicals (i.e. dopamine) in their system–if only temporarily. It helps them feel good and function better with less stress, agitation, and emotional pain. Individuals with these genetic polymorphisms crave substances that will increase dopamine release at the “reward site” in the mesolimbic region of the brain, just to feel normal. These substances often include junk foods, sugars, chocolate, alcohol, nicotine or stimulants. Unfortunately, self-medication only provides temporary relief while bringing with it the possibility of more long-term consequences like weight gain, addictions, and health problems. Repeated episodes of substance abuse can also result in reduced dopamine receptivity and increased cravings even in people with normal dopamine genetics.
Discoveries by Kenneth Blum, Ph.D. and Ernie Noble, Ph.D. regarding the role of genes in determining craving behaviors opened new doors to understanding the genetic reasons why we do what we do and the influence that has on mental and physical health. Further scientific developments reveal new insights about how nutrition influences gene expression; how that influences your overall health (aka ‘Nutrigenomics’); how the brain and body communicate; how the abnormal desire for pleasurable experiences and other unhealthy substances occur; and, most importantly, how they can be corrected. This Research has created an opportunity to incorporate more evidence-based effective, holistic, and comprehensive approaches based on a better understanding of nutrition, neuro-genetics, nutrigenomics, brain cell metabolism and brain healing (Blum et al. 1977; Blum et al. 1996; Blum et al, 2000).
Pleasure-seeking behavior comes from the brain reward circuitry, particularly in the dopamine system (Blum and Wallace, 1974). When dopamine is released, it stimulates receptors (D1-D5) that reduce stress, thereby creating a sense of pleasurable well-being (Blum et al, 2009a). Dopamine release is the normal reward for satisfying an individual’s most basic drives for food, reproduction, pleasure, and safety. Dopamine is also involved in aspects of focus, concentration, energy, and stress tolerance among other roles.
One of the primary therapeutic protocols used in most recovery programs involves behavioral modification using positive affirmations and reinforcement. This approach will be referred to as “software therapy”, a term coined by Dr. John Giordano. Emerging science provides new and exciting approaches that augment this software therapy by incorporating a novel nutraceutical neuroadaptogen therapy to help support healthy cravings, enhanced energy, and reduced stress; and maintain a healthy mood, optimal brain health, and overall wellness.* This approach is referred to as “hardware therapy”, a term also coined by Dr. Giordano, because it directly promotes healthy brain biochemistry with the use of LifeGen’s nutrigenomic neuroadaptogen tools. LifeGen’s patented KB220 and KB220Z nutraceutical ‘neuroadaptagen’ technology, known as SynaptaGenX™, has been shown to reduce or eliminate excessive desires for unhealthy behaviors and pleasure-inducing substances by supporting healthy cravings through the positive influence on gene expression.
Under normal conditions in the “reward system” of the brain, the neurotransmitter dopamine stimulates certain dopamine receptors that signal feelings of pleasure and well-being; reduce the effects of stress (increase stress tolerance); and promote satisfaction, satiety, and happiness. Certain gene variations, or polymorphisms, in the “brain reward cascade” cause the brain to need increased amounts of dopamine to feel good, i.e. a “dopamine fix.” This condition is also called ‘dopamine resistance,’ which can cause excessive pleasure/reward seeking behaviors.
These behaviors include psychostimulant use/abuse, gambling, thrill seeking behaviors, sexual deviance, ADHD, and more; all done to get that dopamine fix. This results in a condition called “Reward Deficiency Syndrome” (RDS). Importantly, people who experience RDS also engage in excessive unhealthy craving behaviors to get that dopamine fix; are more prone to excess sugar and fat cravings and intake; generally overeat; and experience metabolic disruption. These people have the greatest genetic predispositions to and highest incidence of dopamine resistance.
SynaptaGenX ™ has been shown in numerous studies to promote dopamine sensitivity, which has many systemic benefits that contribute to supporting healthy cravings; reducing stress; improving focus and concentration; increasing feelings of happiness; and improving overall health and metabolism.
SynaptaGenX ™ has been shown to measurably increase dopamine, as well as serotonin, and endorphins, important neurotransmitters responsible for brain reward.
SynaptaGenX ™, is a patented dopamine agonist (US # 6,132,724, US # 6,955,873) that promotes healthy dopamine metabolism that supports optimal brain health. This cutting-edge patented composition increases the satisfaction from pleasurable experiences through supplying neuro-nutraceuticals that are beneficial to healthy brain function.
These neuro-nutrients help promote optimal dopamine function; normalize satiety and pleasure satisfaction from normally enjoyable activities and experiences; improve energy regulation; reduce stress; promote well-being; and increase feelings of happiness. Importantly, these benefits help to promote healthy improvements in body composition and sustainable weight management.
“GO SOBER™ recommends SynaptaGenX (SGX) all-natural amino acid supplement to support dopamine, serotonin, and endorphin production, the body’s natural reward chemicals. Facilitating the body’s natural production of these chemicals helps increase enjoyment and calmness while reducing stress and anxiety, all of which help support sobriety.”
SynaptaGenX ™ is a proprietary KB220Z neuro-nutraceutical adaptagen formula that has been used in extensive clinical trials as well as pre-clinical animal studies. These studies, conducted by leading universities and medical schools, including the University of California, Massachusetts Institute of Technology, John Hopkins, Yale University, University of Texas, Stonybrook University, National Institute of Drug Abuse, University of Tulane, Concordia, McGill, Toronto, Chicago, Milan, Rome and the University of Colorado, are completed and ongoing. The completed data has been published in U.S. and foreign journals, including Science, Nature, Lancet, Molecular Psychiatry, Alcohol, Archives General Psychiatry, Biochemical Pharmacology, Gene therapy & Molecular Biology, Current Neuropharmacology, Theoretical Biology and Medical Modeling, Medical Hypotheses, Psychopharmacology, British Journal of Pharmacology and JAMA. There are 21 (so far at this writing) peer reviewed published clinical trials validating the efficacy of this groundbreaking technology.
Utilizing a Patent-Pending Liposomal Technology*
PHENYLKETONURICS-CONTAINS PHENYLALANINE although not as a sweetener. Cautions: Schizophrenics should not use a dopamine agonist. If you are pregnant, nursing, or under 12 years of age, consult a physician. KEEP THIS AND ALL DIETARY SUPPLEMENTS OUT OF REACH OF CHILDREN
This product was made in a GMP and ISO 9001:2008 registered facility.
Adults, as a dietary supplement, take 2 tablets (one serving) 2 times per day on an empty stomach preferably 1 hour before or 2 hours after a meal, or as directed by your health care professional. Do not take with protein.
Contains no sugar, soy protein, corn, wheat, gluten dairy, artificial flavors or colors.
Store in a cool, dry place (59°F-85°F) away from direct light. Keep out of reach of children.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.